EPA Home PageSuperfund Risk Assessment Home Page


Health Effects Assessment Summary (HEAST) for

Barium

CAS: 007440-39-3

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Alternative Methods
Chronic [RfC]:on-Line
Subchronic [RfC]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 7E-2 mg/kg/day

Uncertainty Factor: 3

Route: Oral: water

Target Organ / Critical Effect: Cardiovascular system / Increased blood pressure

Species Effect Level Dose Experiment Length
Human NOAEL 0.21 mg/kg/day 10 weeks

References
1990 Wones, R.G., B.L. Stadler, L.A. Frohman. 1990. Lack of effect of drinking water Barium on cardiovascular risk factor. Environ Health Perspect. 85: 1-13.
1984 Brenniman, GR, PS Levy. 1984. High Barium levels in public drinking water and its association with elevated blood pressure. In: Advances in Modern Toxicology IX, EJ Clalbrese, ed. Princeton Scientific Publications, Princeton, NJ. P231-249.
1985 U.S. EPA. 1985. Drinking water criteria document for Barium. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Drinking Water, Washington, DC Ext review draft. Final draft (on public comment). NTIS PB 86-118031/as.
1990 U.S. EPA. 1990. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].





Alternate Methods -- Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfC]:
(see comment)		 5E-4 mg/cu m

Uncertainty Factor: 1000

Subchronic [RfC]:
(see comment)		 5E-3 mg/cu m

Uncertainty Factor: 100

Route: Inhalation: intermittent

Target Organ / Critical Effect: Fetus / Fetotoxicity

Species Effect Level Dose Experiment Length
Rat NOEL 0.8 mg/cu m 4 months

References
1977 Tarasenko M., O. Promin, and A. Silayev. 1977. Barium compounds as industrial poisons (an experimental study). J Hyg Epidem Microbiol Immunol. 21: 361.
1984 U.S. EPA. 1984. Health effects assessment for Barium. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.
Subchronic [RfC] Comments: 1E-3 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST). Based on a reproduction study.
Chronic [RfC] Comments: 1E-3 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST). Based on a reproduction study.
General Comments: The subchronic and chronic inhalation [RfC] values were derived from methodology that is not current with the interim inhalation methodology used by the RfD/RfC work group.


[ Risk Assessment Home ]
[ EPA Home | OSWER Home | Superfund Home ]
[ Search EPA | Search Superfund | Whats New | Contact Us ]
Horizontal Rule
URL: http://risk.lsd.ornl.gov/epa/heast/heast_select.htm
This page was last updated on: March 1, 2000
Site maintained by: Office of Emergency and Remedial Response
Hofmann.Lee@epamail.epa.gov
Horizontal Rule