Health Effects Assessment Summary (HEAST) for
Atrazine
CAS: 001912-24-9
| Summary of HEAST Information on-Line | ||||||||
| Subchronic and Chronic Toxicity | ||||||||
| ||||||||
| Carcinogenicity | ||||||||
|
| Subchronic [RfD]: (see comment) |
3.5E-2 mg/kg/day | |||
| Uncertainty Factor: | 100 | |||
| Route: | Oral: diet | |||
| Target Organ / Critical Effect: | Whole body / Decreased weight gain | |||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | NOEL | 3.5 mg/kg/day | 2 years | |
| References | ||||
| 1986 | Ciba-Geigy Corp. 1986. MRID No. 00141874, 00157875, 00158930, 40629302. HED Doc No. 005940, 006937. Available from EPA. Write to FOI, EPA, Washington, DC 20460. | |||
| 1987 | Ciba-Geigy Corp. Agricultural Division. 1987. MRID No. 40431301, 41293801. HED Doc No. 006718, 006937, 007647. Available from EPA. Write to FOI, EPA, Washington, DC 20460. | |||
| 1992 | U.S. EPA. 1992. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
| Oral [Slope Factor]: (see comment) |
2.22E-1 (mg/kg/day)-1 | |||
| Oral [Unit Risk]: | 6.3E-6 (µg/L)-1 | |||
| Route: | Oral: diet | |||
| Target Organ / Cancer: | Mammary gland / Adenoma | |||
| Mammary gland / Fibroadenoma | ||||
| Mammary gland / Adenocarcinoma | ||||
| Mammary gland / Carcinosarcoma | ||||
| Species | Experiment Length | EPA Group | ||
| Rat | 2 years | C | ||
| References | ||||
| 1986 | Ciba-Geigy. 1986. Two-year feeding study in the rat. Conducted by American Biogenics Corp. MRID No. 262714-262727. Available from EPA, write to FOI, EPA, Washington, DC 20460. | |||
| 1984 | U.S. EPA. 1984. Health and environmental effects profile for Atrazine. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. | |||
| 1990 | U.S. EPA. 1990. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group. | |||
| Oral Slope Comment: | Under review, number subject to change. | |||
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