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Health Effects Assessment Summary (HEAST) for

Arsenic, Inorganic

CAS: 007440-38-2

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 3E-4 mg/kg/day

Uncertainty Factor: 3

Route: Oral

Target Organ / Critical Effect: Skin / Keratosis
Skin / Hyperpigmentation

Species Effect Level Dose
Human NOAEL 0.009 mg/L

References
1977 Tseng W.P. 1977. Effects and dose-response relationships of skin cancer and blackfoot disease with Arsenic. Environ Health Perspect. 19: 109-119.
1968 Tseng, W.P., H.M. Chu, S.W. Hou, J.M. Fong, C.S. Lin, S. Yeh. 1968. Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan. J Natl Cancer Inst. 40: 453-463.
1990 U.S. EPA. 1990. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].


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