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Health Effects Assessment Summary (HEAST) for
Aramite
CAS: 000140-57-8
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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| Carcinogenicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Subchronic [RfD]: |
1E-1 mg/kg/day |
| Uncertainty Factor: |
100 |
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| Route: |
Oral: diet |
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| Target Organ / Critical Effect: |
Liver / Degeneration |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Dog |
NOAEL |
500 ppm |
52 weeks |
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| References |
| 1962 | Oser B.L., M. Oser. 1962. 2-(p-tert-Butylphenoxy)isopropyl 2-Chloroethyl Sulfite (Aramite) II. Carcinogenicity. Toxicol Appl Pharmacol. 4: 70-88. |
| 1989 | U.S. EPA. 1989. Health and environmental effects document for Aramite. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
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| Chronic [RfD]: |
5E-2 mg/kg/day |
| Uncertainty Factor: |
100 |
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| Route: |
Oral: diet |
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| Target Organ / Critical Effect: |
Liver / Increased weight |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
NOAEL |
100 ppm |
104 weeks |
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| References |
| 1960 | Popper H., S.S. Sternberg, B.L. Oser and M. Oser. 1960. The carcinogenic effect of Aramite in rats. Cancer. 13(5): 1035-1046. |
| 1962 | Oser B.L. and M. Oser. 1962. 2-(p-tert-Butylphenoxy)isopropyl 2-Chloroethyl Sulfite (Aramite). Carcinogenicity. Toxicol Appl Pharmacol. 4: 70-88. |
| 1989 | U.S. EPA. 1989. Health and environmental effects document for Aramite. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
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Carcinogenicity |
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Inhalation [Slope Factor]:
(see comment) | 2.5E-2 (mg/kg/day)-1 |
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| Route: |
Oral: diet |
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| Target Organ / Cancer: |
Liver / Tumors |
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| Species |
Experiment Length |
EPA Group |
| Rat |
104 wks |
IRIS |
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| References |
| 1962 | Oser B.L., and M. Oser. 1962. 2-(p-tert-Butylphenoxy)isopropyl 2-chloroethyl sulfite (Aramite). II. Carcinogenicity. Toxicol Appl Pharmacol. 4: 70-88. |
| 1960 | Popper H., S.S. Steinberg, B.L. Oser, and M. Oser. 1960. The carcinogenic effect of Aramite in rats. Cancer. 13(5): 1035-1046. |
| 1989 | U.S. EPA. 1989. Health and environmental effects document for Aramite. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH, for the Office of Solid Waste and Emergency Response, Washington, DC. |
| 1991 | U.S. EPA. 1991. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group. |
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| Inhalation Slope Comment: |
Based on route to route extrapolation. See Appendix A-II, Dose Conversions on HEAST. |
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