Health Effects Assessment Summary (HEAST) for
Antimony Trioxide
CAS: 001309-64-4
| Summary of HEAST Information on-Line | ||||||||||
| Subchronic and Chronic Toxicity | ||||||||||
|
| Chronic [RfD]: (see comment) |
4E-4 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Subchronic [RfD]: (see comment) |
4E-4 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Route: | Oral: drinking water | |||
| Target Organ / Critical Effect: | Whole body / Increased mortality | |||
| Blood / Altered chemistries | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | LOAEL | 0.42 mg/kg/day | Lifetime | |
| References | ||||
| 1970 | Schroeder H.A., M. Mitchener and A.P. Nason. 1970. Zirconium, Niobium, Antimony and Lead in rats: Life-time studies. J Nutr. 100: 59-69. | |||
| 1987 | U.S. EPA. 1987. Health effects assessment for Antimony and compounds. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC | |||
| 1985 | U.S. EPA. 1985. Health and environmental effects profile for Antimony Oxides. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC | |||
| Subchronic [RfD] Comments: | Calculated by analogy to antimony by correcting for differences in molecular weight. | |||
| Chronic [RfD] Comments: | Calculated by analogy to Antimony by correcting for differences in molecular weight. | |||
| Subchronic [RfC]: (see comment) |
2E-4 mg/cu m | |||
| Uncertainty Factor: | 30 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Lung / Pulmonary toxicity | |||
| Lung / Interstitial inflammation, chronic | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | BMC | 0.87 mg/cu m | 1 year | |
| References | ||||
| 1994 | Newton P.E., H.F. Bolts, I.W. Daly et al. 1994. Subchronic and chronic inhalation toxicity of Antimony Trioxide in the rat. Fund Appl Toxicol 32:561-576. | |||
| 1995 | U.S. EPA. 1995. RfD/RfC Work Group. | |||
| Subchronic [RfC] Comments: | The chronic inhalation RfC is adopted as the subchronic inhalation [RfC]. | |||
[ Risk Assessment Home ]
[ EPA Home |
OSWER Home | Superfund Home ]
[ Search EPA
| Search Superfund
| Whats New |
Contact Us ]
URL: http://risk.lsd.ornl.gov/epa/heast/heast_select.htm
This page was last updated on: March 1, 2000
Site maintained by: Office of Emergency and Remedial Response
Hofmann.Lee@epamail.epa.gov