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Health Effects Assessment Summary (HEAST) for

Ammonia

CAS: 007664-41-7

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line
Chronic [RfC]:IRIS
Subchronic [RfC]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]:
(see comment)		 34 mg/L

Uncertainty Factor: 1

Subchronic [RfD]:
(see comment)		 34 mg/L

Uncertainty Factor: 1

Route: Oral: drinking water

Target Organ / Critical Effect: Sensory / Taste threshold

Species Effect Level Dose
Human NOAEL 34 mg/L

References
1958 Campbell C.L., R.K. Dawes, S. Deolalkar and M.C. Merritt. 1958. Effect of certain chemicals in water on the flavor of brewed coffee. Food Res. 23: 575-579. Cited in U.S. EPA, 1981.
1986 WHO (World Health Organization). 1986. Environmental Health Criteria. 54. Ammonia. WHO, Geneva, Switzerland.
1981 U.S. EPA. 1981. Ambient water quality criterion for the protection of human health: Ammonia. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water Regulations and Standards, Washington, DC
1987 U.S. EPA. 1987. Health effects assessment for Ammonia. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC
Subchronic [RfD] Comments: Given as concentration in drinking water. Specifically related to organoleptic threshold. Safe concentration may be higher, but data are inadequate to assess.
Chronic [RfD] Comments: Given as concentration in drinking water. Specifically related to organoleptic threshold. Safe concentration may be higher, but data are inadequate to assess.




Subchronic [RfC]: 1E-1 mg/cu m
Uncertainty Factor: 30

Route: Inhalation: intermittent

Target Organ / Critical Effect: Nasal cavity / Rhinitis
Lungs / Pneumonia
Lungs / Lesions

Species Effect Level Dose
Human NOAEL 6.4 mg/cu m

References
1989 Holness D.L., J.T. Purdham and J.R. Nethercott. 1989. Acute and chronic respiratory effects of occupational exposure to Ammonia. Am Ind Hyg Assoc J. 50: 646-650.
1976 Broderson J.R., J.R. Lindsey and J.E. Crawford. 1976. The role of environmental Ammonia in respiratory mycoplasmosis of rats. Am J Pathol. 85: 115-130.
1991 U.S. EPA. 1991. RfD/RfC Work Group.


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