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Health Effects Assessment Summary (HEAST) for
Aminopyridine, 4-
CAS: 000504-24-5
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Chronic [RfD]: |
2E-5 mg/kg/day |
| Uncertainty Factor: |
10000 |
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| Subchronic [RfD]: |
2E-4 mg/kg/day |
| Uncertainty Factor: |
1000 |
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| Route: |
Oral: diet |
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| Target Organ / Critical Effect: |
Liver / Increased weight |
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Brain / Increased weight |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
NOAEL |
3 ppm |
90 days |
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| References |
| 1968 | Kohn F.E. 1968. Four-week subacute oral toxicity of compound 1861 Hydrochloride -- albino rats. (unpublished study). Prepared by Industrial Biotest Laboratories, Inc. Under 224-12. Submitted by Phillips Petroleum Co., Bartlesville, OK. CDL: 229844-E. |
| 1980 | U.S. EPA. 1980. 4-Aminopyridine. Avitrol pesticide registration standard. Prepared by the Office of Pesticide Programs, U.S. EPA, Washington, DC NTIS PB84-209907. |
| 1989 | U.S. EPA. 1989. Health and environmental effects document for 4-Aminopyridine. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
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