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Health Effects Assessment Summary (HEAST) for

Aldrin

CAS: 000309-00-2

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 3E-5 mg/kg/day

Uncertainty Factor: 1000

Route: Oral: diet

Target Organ / Critical Effect: Liver / Lesions

Species Effect Level Dose Experiment Length
Rat LOAEL 0.025 mg/kg/day 2 years

References
1964 Fitzhugh O.G., A.A. Nelson and M.L. Quaife. 1964. Chronic oral toxicity of Aldrin and Dieldrin in rats and dogs. Food Cosmet Toxicol. 2: 551-562.
1987 U.S. EPA. 1987. Health effects assessment for Aldrin. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1985 U.S. EPA. 1985. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].





Carcinogenicity
Inhalation [Slope Factor]:
(see comment)		1.7E+1 (mg/kg/day)-1


Route: Oral: diet

Target Organ / Cancer: Liver / Carcinoma

Species EPA Group
Mouse IRIS

References
1975 Epstein S.S. 1975. The carcinogenicity of Dieldrin, Part I. Sci Total Environ. 4: 1-52.
1977 NCI (National Cancer Institute). 1977. Bioassays of Aldrin and Dieldrin for possible carcinogenicity. NCI Carcinogenesis Tech Rep Ser NO 21. NCI-C6-TR-66 DHEW Publication No. (NIH) 78-821.
1962 Davis K.J., and O.G. Fitzhugh. 1962. Tumorigenic potential of Aldrin and Dieldrin for mice. Toxicol Appl Pharmacol. 4: 187-189.
1965 Davis K.J. 1965. Pathology report on mice for Aldrin, Dieldrin, Heptachlor, or Heptachlor Epoxide for two years. Int Food Drug Admin.
1986 U.S. EPA. 1986. Carcinogenicity assessment of Aldrin and Dieldrin. Prepared by the Office of Health and Environmental Assessment, Carcinogen Assessment Group, Washington, DC.
1987 U.S. EPA. 1987. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
Inhalation Slope Comment: See Appendix A-II, Dose Conversions on HEAST.


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