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Health Effects Assessment Summary (HEAST) for

Aldicarb

CAS: 000116-06-3

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 1E-3 mg/kg/day

Uncertainty Factor: 10

Route: Oral

Target Organ / Critical Effect: Central nervous system / Sweating

Species Effect Level Dose Experiment Length
Human NOAEL 0.01 mg/kg-day Acute

References
1992 Rhone-Poulenc Ag Company. 1992. MRID No. 423730-01. HED Doc. No. 010459. Available from EPA. Write to FOI, EPA, Washington, DC 20460
1971 Union Carbide Corp. 1971. R. Haines, J.B. Dernehl, J.B. Block, Supervising Physicians. Ingestion of Aldicarb by human volunteers: A controlled study of the effects of Aldicarb on man. ALD-03-77-2215. Feb 11, 1971. MRID No. 00101911. HED Doc. No. 010450. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
1990 Goldman L.R., M. Beller, R.J. Jackson. 1990. Aldicarb food poisoning in California, 1985-1988: Toxicity estimates for humans. Arch Environ Health. 45(3): 141-147. HED Doc. No. 010451, 010455, 010458. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
1990 Goldman L.R., D.F. Smith, R.R. Neutra et al. 1990. Pesticide food poisoning from contaminated watermelons in California, 1985. Arch Environ Health. 45(4): 229-236.
1987 Hirsch G.H., B.T. Mori, G.B. Morgan, P.R. Bennet, B.C. Williams. 1987. Report of illnesses caused by Aldicarb-contaminated cucumbers. Food Additives and Contaminants. 5(2): 155-60. HED Doc. No. 010455, 010458. Available from EPA. Write to FOI, EPA, Washington, DC 020460.
1992 U.S. EPA. 1992. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].
General Comments: Clinical signs of Acetyl Cholinesterase inhibition including sweating, pinpoint pupils, leg weakness, nausea, diarrhea and other effects were observed in the principal and supporting studies.


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