Health Effects Assessment Summary (HEAST) for
Alachlor
CAS: 015972-60-8
| Summary of HEAST Information on-Line | ||||||||
| Subchronic and Chronic Toxicity | ||||||||
| ||||||||
| Carcinogenicity | ||||||||
|
| Subchronic [RfD]: (see comment) |
1E-2 mg/kg/day | |||
| Uncertainty Factor: | 100 | |||
| Route: | Oral: capsule | |||
| Target Organ / Critical Effect: | Blood / Anemia | |||
| Sites, multiple / Hemosiderosis | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Dog | NOEL | 1 mg/kg/day | 1 year | |
| References | ||||
| 1984 | Monsanto Co. 1984. MRID No. 00148923. Available from EPA. Write to FOI, EPA, Washington, DC, 20460. | |||
| 1992 | U.S. EPA. 1992. Health and environmental effects document for Alachlor. Prepared by the Environmental Criteria and Assessment Office of the Office of Health and Environmental Assessment, Cincinnati, OH, for the Office of Solid Waste and Emergency Response, Washington, DC | |||
| 1984 | U.S. EPA. 1984. Health and environmental effects profile for Alachlor. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC | |||
| 1991 | U.S. EPA. 1991. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
| Oral [Slope Factor]: (see comment) |
8E-2 (mg/kg/day)-1 | |||
| Oral [Unit Risk]: | 2.3E-6 (µg/L)-1 | |||
| Route: | Oral: diet | |||
| Target Organ / Cancer: | Multiple sites / Tumors | |||
| EPA Group | ||||
| B2 | ||||
| References | ||||
| 1983 | Stout L.D., et al. 1983. A chronic study of Alachlor administered in feed to Long-Evans rats. EHL #800218, Project No. ML-80-186, Report MSL-3282/3284. Vol. I and II. Unpublished study received Feb. 28, 1984 under U.S. EPA Reg. No. 524-316, prepared by Monsanto Environmental Health Laboratory (EHL), submitted by Monsanto Co., Washington, DC. CDL:252496-7. | |||
| 1984 | U.S. EPA. 1984. Health and environmental effects profile for Alachlor. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. | |||
| 1992 | U.S. EPA. 1992. Health and environmental effects document for Alachlor. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. | |||
| 1988 | U.S. EPA. 1988. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group. | |||
| Oral Slope Comment: | Under review, number subject to change. | |||
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