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Health Effects Assessment Summary (HEAST) for

Acrylonitrile

CAS: 000107-13-1

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]: 1E-3 mg/kg/day
Uncertainty Factor: 1000

Subchronic [RfD]:
(see comment)		 1E-2 mg/kg/day

Uncertainty Factor: 100

Route: Oral: gavage

Target Organ / Critical Effect: Testes / Decreased sperm counts
Testes / Seminiferous tubule degeneration

Species Effect Level Dose Experiment Length
Mouse NOAEL 1 mg/(kg-day) 60 days

References
1988 Tandon R., D.K. Saxena, S.V. Chandra, P.K. Seth, S.P. Srivastava. 1988. Testicular effects of Acrylonitrile in mice. Toxicology Letters. 42: 55-63.
1980 Biodynamics. 1980. A twenty-four month oral toxicity/carcinogenicity study of Acrylonitrile administered to Spartan rats in the drinking water, Vol 1-2. Prepared by Biodynamics, Inc., Division of Biology and Safety Evaluation, East Millstone, NJ, for Monsanto Company, St. Louis, MO.
1993 U.S. EPA. 1993. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral [RfD] under review by the RfD/RfC work group was modified to estimate the subchronic oral [RfD].





Carcinogenicity
Inhalation [Slope Factor]:
(see comment)		2.4E-1 (mg/kg/day)-1


Route: Inhalation: occupational

Target Organ / Cancer: Lung / Tumors

Species EPA Group
Human IRIS

References
1980 O'Berg M. 1980. Epidemiologic study of workers exposed to Acrylonitrile. J Occup Med 22: 245-252.
1983 U.S. EPA. 1983. Health assessment document for Acrylonitrile. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Research Triangle Park, NC.
1987 U.S. EPA. 1987. Health effects assessment for Acrylonitrile. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington DC.
1987 U.S. EPA. 1987. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
Inhalation Slope Comment: See Appendix A-II, Dose Conversions on HEAST.


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