HEAST Summary

Health Effects Assessment Summary (HEAST) for
Acrylic Acid

CAS: 000079-10-7

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfD]: IRIS

Subchronic [RfD]: on-Line

Chronic [RfC]: IRIS

Subchronic [RfC]: on-Line

Notes/Comments: on-Line


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: (see comment)	5E-1 mg/kg/day

Uncertainty Factor:	100

Route:	Oral: drinking water

Target Organ / Critical Effect:	Whole body / Decreased pup weight

Species	Effect Level	Dose	Experiment Length
Rat	NOAEL	53 mg/kg/day	2 generation

References
1993	BASF. 1993. Reproduction toxicity study with Acrylic acid in rats: Continuous administration in the drinking water over 2 generations (1 litter in the first and 1 litter in the second generation). Project No. 71R0114/92011. BASF Aktiengellschaft, Dept. of Toxicology, Rhein, FRG.
1994	U.S. EPA. 1994. RfD/RfC Work Group.

Subchronic [RfD] Comments:	The chronic oral RfD on IRIS was adopted as the subchronic oral [RfD].


Subchronic [RfC]:	3E-3 mg/cu m
Uncertainty Factor:	100

Route:	Inhalation: intermittent

Target Organ / Critical Effect:	Nasal mucosa / Lesions

Species	Effect Level	Dose	Experiment Length
Mouse	LOAEL	5 ppm	13 weeks

References
1981	Miller, R.R., J.A. Ayers, G.C. Jersey and M.J. McKenna. 1981. Inhalation toxicity of Acrylic Acid. Fund Appl Toxicol. 1(3): 271-277.
1979	Miller, R.R., J.A. Ayers, G.C. Jersey. 1979. Acrylic acid 90-day vapor inhalation study with rats and mice. Final report #79 RC-1024. Toxicology Research Laboratory, Health and Environmental Science, Dow Chemical Company, Midland, MI.
1990	U.S. EPA. 1990. RfD/RfC Work Group.

[ Risk Assessment Home ]
[ EPA Home | OSWER Home | Superfund Home ]
[ Search EPA | Search Superfund | Whats New | Contact Us ]

URL: http://risk.lsd.ornl.gov/epa/heast/heast_select.htm
This page was last updated on: March 1, 2000
Site maintained by: Office of Emergency and Remedial Response
Hofmann.Lee@epamail.epa.gov