HEAST Summary

Health Effects Assessment Summary (HEAST) for
Acrylamide

CAS: 000079-06-1

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfD]: IRIS

Subchronic [RfD]: on-Line

Chronic [RfC]: IRIS

Carcinogenicity

Oral [Slope Factor]: IRIS

Inhalation [Slope Factor]: on-Line

Oral [Unit Risk]: IRIS

Inhalation [Unit Risk]: IRIS

EPA Group: IRIS

Notes/Comments: on-Line


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:	2E-3 mg/kg/day
Uncertainty Factor:	100

Route:	Oral: drinking water

Target Organ / Critical Effect:	Nerve / Damage

Species	Effect Level	Dose	Experiment Length
Rat	NOEL	0.2 mg/kg/day	90 days

References
1980	Burek J.D., R.R. Albee, J.E. Beyer, et al. 1980. Subchronic toxicity of Acrylamide administered to rats in the drinking water followed by up to 144 days of recovery. J Environ Pathol Toxicol. 4: 157-182.
1985	U.S. EPA. 1985. Health and environmental effects profile for Acrylamide. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1988	U.S. EPA. 1988. RfD/RfC Work Group.


Carcinogenicity

Inhalation [Slope Factor]: (see comment)	4.5E+0 (mg/kg/day)^-1


Route:	Oral: drinking water

Target Organ / Cancer:	Mammary / Tumors
	Thyroid / Tumors
	Uterus / Tumors
	Oral cavity / Tumors
	Central nervous system / Tumors

Species	Experiment Length	EPA Group
Rat	2 years	IRIS

References
1986	Johnson K., S. Gorzinski, K.M. Bodner, et al. 1986. Chronic toxicity and oncogenicity study on Acrylamide incorporated in the drinking water of Fischer 344 rats. Dow Chemical, U.S.A, Midland, MI.
1985	U.S.EPA. 1985. Health and environmental effects profile for Acrylamide. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
1988	U.S.EPA. 1988. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.

Inhalation Slope Comment:	See Appendix A-II, Dose Conversions on HEAST.

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