Health Effects Assessment Summary (HEAST) for
Acetonitrile
CAS: 000075-05-8
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
| ||||||
| Alternative Methods | ||||||
|
| Subchronic [RfD]: (see comment) |
6E-2 mg/kg/day | |||
| Uncertainty Factor: | 300 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Erythrocytes / Decreased cell count | |||
| Blood / Decreased hematocrit | ||||
| Liver / Hepatic lesions | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Mouse | NOAEL | 100 ppm | 92 days | |
| References | ||||
| 1983 | National Toxicology Program (NTP). 1983. 90-day subchronic toxicity studies of Acetonitrile in rats and mice. Report to National Toxicology Program. | |||
| 1987 | U.S. EPA. 1987. Health effects assessment for Acetonitrile. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC | |||
| 1987 | U.S. EPA. 1987. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | Based on route to route extrapolation using an absorption factor of 0.5. | |||
| Chronic [RfC]: (see comment) |
5E-2 mg/cu m | |||
| Uncertainty Factor: | 3000 | |||
| Subchronic [RfC]: (see comment) |
5E-1 mg/cu m | |||
| Uncertainty Factor: | 300 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Liver / Increased relative weight | |||
| Species | Effect Level | Dose | Experiment Length | |
| Mouse | NOAEL | 100 ppm | 92 days | |
| References | ||||
| 1983 | Coate W.B. 1983. 90-day subchronic toxicity study of Acetonitrile in B6C3F1 mice. Final Report (revised). | |||
| 1987 | U.S. EPA. 1987. Health effects assessment for Acetonitrile. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC. | |||
| Subchronic [RfC] Comments: | 1E-1 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST). | |||
| Chronic [RfC] Comments: | 1E-2 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST). Under review, current number subject to change. | |||
| General Comments: | The subchronic and chronic inhalation [RfC] values were derived from methodology that is not current with the interim inhalation methodology used by the RfD/RfC work group. | |||
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