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Health Effects Assessment Summary (HEAST) for

Acetone Cyanohydrin / (2-Methyllactonitrile)

CAS: 000075-86-5

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line
Alternative Methods
Chronic [RfC]:on-Line
Subchronic [RfC]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]: 8E-4 mg/kg/day
Uncertainty Factor: 3000

Subchronic [RfD]: 8E-3 mg/kg/day
Uncertainty Factor: 300

Route: Oral: gavage

Target Organ / Critical Effect: Liver / Increased relative weight

Species Effect Level Dose Experiment Length
Rat NOAEL 8.75 mg/kg-day 90 days

References
1988 Hazelton Laboratories America. 1988. Subchronic toxicity study in rats with 2-Methyllactonitrile. HLA Study No. 2399-114. Report prepared for Dynamac Corporation.
1994 U.S. EPA. 1994. RfD/RfC Work Group.





Alternate Methods -- Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfC]:
(see comment)		 1E-2 mg/cu m

Uncertainty Factor: 1000

Subchronic [RfC]:
(see comment)		 1E-1 mg/cu m

Uncertainty Factor: 100

Route: Inhalation: intermittent

Target Organ / Critical Effect: Central nervous system / Effects

Species Effect Level Dose Experiment Length
Rat NOEL 4.0 mg/kg/day 14 weeks

References
1984 Blank T.L. and D.C. Thake. 1984. Three-month inhalation toxicity of Acetone Cyanohydrin in male and female Sprague-Dawley rats. Monsanto Report NOP. MSL-4423. TSCA 8(D) Submission 878216397 (OTSO510325).
1988 U.S. EPA. 1988. Health and environmental effects document for Cyanohydrins. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
Subchronic [RfC] Comments: 4E-2 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST). An error in the uncertainty factor that was reported in HEED (1988) was corrected.
Chronic [RfC] Comments: 4E-2 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST).
General Comments: The subchronic and chronic inhalation [RfC] values were derived from methodology that is not current with the interim inhalation methodology used by the RfD/RfC work group.


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