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Health Effects Assessment Summary (HEAST) for

Acetone

CAS: 000067-64-1

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: 1E+0 mg/kg/day
Uncertainty Factor: 100

Route: Oral: gavage

Target Organ / Critical Effect: Liver / Increased weight
Kidney / Increased weight
Kidney / Nephrotoxicity

Species Effect Level Dose Experiment Length
Rat NOEL 100 mg/kg/day 90 days

References
1986 U.S. EPA. 1986. Ninety-day gavage study in albino rats using Acetone. Office of Solid Waste and Emergency Response, Washington, DC
1988 U.S. EPA. 1988. Updated health effects assessment for Acetone. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC
1986 U.S. EPA. 1986. RfD/RfC Work Group.


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