Toxicity Profiles

RAGs A Format for Indeno[1,2,3-cd]pyrene - CAS Number 193395

Indeno[1,2,3-cd]pyrene is a polycyclic aromatic hydrocarbon (PAH) with one five-membered carbon ring and five six-membered carbon rings. It is a crystalline solid that is insoluble in water but is soluble in organic solvents. There is no commercial production or known use of indeno[1,2,3-cd]pyrene. The compound is found in fossil fuels and occurs ubiquitously in products of incomplete combustion. It has been detected in mainstream cigarette smoke; gasoline engine exhaust; emissions from burning coal; lubricating oils; used motor oils; and soils, surface waters, and groundwater at hazardous waste sites.

No absorption data were available for indeno[1,2,3-cd]pyrene; however, by analogy to structurally-related PAHs, it would be expected to be absorbed from the digestive tract, lungs, and skin. No data were found concerning the acute, subchronic, chronic, developmental, or reproductive toxicity of indeno[1,2,3-cd]pyrene.

No long-term oral or inhalation human bioassays were available to assess the carcinogenicity of indeno[1,2,3-cd]pyrene. The compound was tested for carcinogenicity in dermal application, lung implant, subcutaneous injection, and intraperitoneal injection studies in animals. Dermal application produced skin papillomas and carcinomas in mice. Lung implants produced epidermoid carcinomas in rats. Injection site sarcomas developed in mice given injections of indeno[1,2,3-cd]pyrene. Based on no human data and sufficient evidence for carcinogenicity in animals, the United Stated Environmental Protection Agency (EPA) has assigned a weight-of-evidence classification of B2, probable human carcinogen to indeno[1,2,3-cd]pyrene.

The following is a presentation of the toxicity information associated with Indeno[1,2,3-cd]pyrene.

• The Oral Slope Factor is 7.30E-01 (mg/kg-day)^-1.
• The Inhalation Unit Risk is 8.8E-02 (mg/m³)^-1.
• The Dermal Slope Factor is 2.35E+00 (mg/kg-day)^-1.
• The Dermal Slope Factor is based on a gastrointestinal absorption factor of 0.3100.