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Health Effects Assessment Summary (HEAST) for

Toluene

CAS: 000108-88-3


Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Chronic [RfC]:IRIS






Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: 2E+0 mg/kg/day
Uncertainty Factor: 100

Route: Oral: gavage

Target Organ / Critical Effect: Liver / Altered weight
Kidney / Altered weight

Species Effect Level Dose Experiment Length
Rat NOAEL 223 mg/kg/day 13 weeks

References
1989 NTP (National Toxicology Program). 1989. Toxicology and carcinogenesis studies of Toluene in F344 rats and B6C3F1 mice. Technical Report Series No. 371.
1984 U.S. EPA. 1984. Health effects assessment for Toluene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC
1990 U.S. EPA. 1990. RfD/RfC Work Group.



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