|
|
|
|
Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
|
Subchronic [RfD]: |
2E+0 mg/kg/day |
Uncertainty Factor: |
100 |
|
Route: |
Oral: gavage |
|
Target Organ / Critical Effect: |
Liver / Altered weight |
|
Kidney / Altered weight |
|
Species |
Effect Level |
Dose |
Experiment Length |
Rat |
NOAEL |
223 mg/kg/day |
13 weeks |
|
References |
1989 | NTP (National Toxicology Program). 1989. Toxicology and carcinogenesis studies of Toluene in F344 rats and B6C3F1 mice. Technical Report Series No. 371. |
1984 | U.S. EPA. 1984. Health effects assessment for Toluene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC |
1990 | U.S. EPA. 1990. RfD/RfC Work Group. |
|