HEAST Summary

Health Effects Assessment Summary (HEAST) for
Methoxyethanol, 2-

CAS: 000109-86-4

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfC]: IRIS

Subchronic [RfC]: on-Line

Alternative Methods

Chronic [RfD]: on-Line

Subchronic [RfD]: on-Line

Notes/Comments: on-Line


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfC]:	2E-1 mg/cu m
Uncertainty Factor:	100

Route:	Inhalation: intermittent

Target Organ / Critical Effect:	Testicle / Effects

Species	Effect Level	Dose	Experiment Length
Rabbit	NOAEL	93 mg/cu m	13 weeks

References
1983	Miller R.R., J.A. Ayres, J.L. Young et al. 1983. Ethylene Glycol Monomethyl Ether. I. Subchronic vapor inhalation study with rats and rabbits. Fund Appl Toxicol. 3(1): 49-54.
1990	U.S. EPA. 1990. RfD/RfC Work Group.


Alternate Methods -- Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]: (see comment)	1E-3 mg/kg/day

Uncertainty Factor:	1000

Subchronic [RfD]: (see comment)	1E-2 mg/kg/day

Uncertainty Factor:	100

Route:	Inhalation: intermittent

Target Organ / Critical Effect:	Testicle / Effects

Species	Effect Level	Dose	Experiment Length
Rabbit	NOAEL	31 mg/cu m	13 weeks

References
1982	Miller R.R., L.L. Calhoun, B.L. Yano. 1982. Ethylene Glycol Monoethyl Ether: 13 week vapor inhalation study in male rabbits. Report prepared for the CMA March 25, 1982.
1986	U.S. EPA. 1986. Health and environmental effects profile for 2-Methoxyethanol. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.

Subchronic [RfD] Comments:	Based on route to route extrapolation.
Chronic [RfD] Comments:	Based on route to route extrapolation.

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