Health Effects Assessment Summary (HEAST) for
Ethylene Glycol
CAS: 000107-21-1
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Subchronic [RfD]: (see comment) |
2E+0 mg/kg/day | |||
| Uncertainty Factor: | 100 | |||
| Route: | Oral: diet | |||
| Target Organ / Critical Effect: | Fetus / Fetotoxicity | |||
| Species | Effect Level | Dose | ||
| Rat | NOEL | 200 mg/kg/day | ||
| References | ||||
| 1983 | Maronpot R.R., J.P. Zelenak, E.V. Weaver and N.J. Smith. 1983. Teratogenicity study of Ethylene Glycol in rats. Drug Chem Toxicol. 6(6): 579-594. | |||
| 1987 | U.S. EPA. 1987. Health effects assessment for Ethylene Glycol. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC | |||
| Subchronic [RfD] Comments: | Based on a reproduction study with exposures during days 6-15 of gestation. | |||
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